Kherson was the only regional capital that was captured by Russian forces in the first few days of their invasion in February.
The strategically important city, which borders the illegally annexed Crimea Peninsula, is seen as the ultimate target for Ukraine’s southern counter-offensive.
Russia’s puppet authorities in Kherson earlier this month shelved plans to hold a sham referendum to annex the city as Ukraine’s counter-attack edged closer.
Around the same time as the strike in Kherson, a bomb killed Sergei Gorenko, the LPR’s prosecutor general, in his office alognside his deputy.
Mykhailo Podolyak, one of Volodymyr Zelensky’s closest aides, said Ukraine was not behind the blast, instead blaming an internal mafia dispute.
The Russian-appointed deputy mayor of Berdyansk, in the southern Zaporizhzhia region, and his wife, who was in charge of organising a referendum to join the Russian Federation, were also assassinated near their home.
Oleg Boyko and his wife, Lyudmila, became the fourth and fifth pro-Russian victims when they were killed on Friday in a blast near to their garage, according to local officials.
The attacks will likely unnerve Russia’s local proxies in the war-torn country as pro-Kremlin officials are increasingly targeted by Ukraine’s armed forces and pro-Kyiv partisans.