The trip to Moldova comes off the back of a dispiriting defeat at home to Real Sociedad that got their Group E campaign off to an ignominious start, while Sheriff comfortably beat Omonia before making it three wins in a row on the weekend.
A number of players were rested by the United boss last week and the postponement of the Crystal Palace and Leeds games should push Ten Hag towards a full-strength side on Thursday.
Raphael Varane, Scott McTominay and Marcus Rashford sat out the defeat while Luke Shaw is back in training after a foot injury. However, Rashford and Aaron Wan-Bissaka were not in the 22-man squad picked to travel to face Sheriff.
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Anthony Martial, Donny van de Beek and Facundo Pellistri all miss out alongside Brandon Williams. Ten Hag update fans and revealed Rashford’s injury was not a long-term concern.
“It’s not really bad and we expect him back quite soon in the team,” he said on Wednesday.
A number of young players are also vying to feature with Zidane Iqbal, Charlie McNeil, Radek Vitek and Alejandro Garnacho in the travelling party.
Predicted Manchester United XI: De Gea; Dalot, Varane, Martinez, Malacia; Casemiro, McTominay; Antony, Fernandes, Sancho; Ronaldo.